beta Amyloid anticorps (N-Term)

N° du produit ABIN1105349

L’anticorps Souris Monoclonal anti-beta Amyloid a été validé pour IHC (fro). Il convient pour détecter beta Amyloid dans des échantillons de Humain.

Aperçu rapide pour beta Amyloid anticorps (N-Term) (ABIN1105349)

Antigène: beta Amyloid (Abeta) (Amyloid beta (Abeta))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp beta Amyloid est non-conjugé

Application: Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: NT 6C8

Détail du produit anti-beta Amyloid anticorps

Épitope: N-Term

Séquence: DAEFRHDS

Specificité: This antibody recognizes the N-terminal sequence of beta amyloid peptides.

Réactivité croisée (Details): Species reactivity (tested):Human

Purification: Protein G affinity purified

Immunogène: The N-terminal sequence of human beta amyloid peptides

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Reconstitution: Double distillated water is recommended and to adjust the final concentration to 1.00 mg/mL.

Buffer: 0.01 M PBS pH 7.2

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store at -20 °C.

Détails sur beta Amyloid

Antigène: beta Amyloid (Abeta) (Amyloid beta (Abeta))

Autre désignation: Amyloid beta

Sujet: Beta amyloid, often abbreviated as A-beta, is a protein that builds up in the brains of persons with Alzheimer's disease, collecting in clumps called plaques or senile plaques. While some researchers question whether beta amyloid is the cause of the dementia, most agree that it is involved in the disruption of thinking that is a hallmark of the disease. In some cases of familial Alzheimer's disease, mutations in genes for the proteins called the presenilins lead to increased production of amyloid. Researchers have been looking at how presenilin-1 in particular contributes to the excess buildup of beta amyloid. Presenilin-1 apparently acts to increase the activity of gamma-secretase, an enzyme that changes a normal protein (amyloid precursor protein or APP) into beta amyloid itself. Furthermore, presenilin-1 might be gamma-secretase.Synonyms: ABPP, APPI, Alzheimer disease amyloid protein, Amyloid Precursor Protein, CVAP, Cerebral vascular amyloid peptide, PreA4, Protease nexin-II

ID gène: 351

Pathways: Inflammasome